This urine test looks for a fusion of genes that is present in 50% of prostate-specific antigen tested men with prostate cancer. All rights reserved. Le PSA est une protéine qui circule dans le sang et qui est sécrétée de façon exclusive par la prostate.. Il est possible de doser sa concentration par une prise de sang.Lorsque l’on souffre d’une maladie de la prostate (infection, adénome ou cancer), le taux de PSA augmente.. C’est en cas de cancer que l’augmentation est la plus notable. It's another tool to determine if a man may need a biopsy. Our website services, content, and products are for informational purposes only. A painless urine test could soon help doctors tell when a high prostate specific antigen (PSA) level means a dangerous cancer or when it’s a …
“I hope people will be given hope that the tricky problem of determining the correct course of treatment or no treatment in prostate cancer is on the way to being solved, and that this could be done in a noninvasive way using a simple urine test.” The PUR test has the chance to change the face of prostate cancer and treatment, but more research is needed to see if it contributes to a significant improvement, he said.“I think there’s a high bar for a new test to stand out from the crowd,” said “It’s important for the test to address the outcomes that matter, which are mortality, overdiagnosis, and metastasis, not just diagnostic performance,” she added.© 2005-2020 Healthline Media a Red Ventures Company. The PSA test is a blood test used primarily to screen for prostate cancer.The test measures the amount of prostate-specific antigen (PSA) in your blood. Le PSA est également présent dans le sang en petite quantité, ce qui permet son dosage. Healthline Media does not provide medical advice, diagnosis, or treatment. 3, 2011 -- A painless urine test could soon help doctors tell when a high The test looks for a genetic mistake thatâs present in about half of all cases of This mistake, a case of two genes that come together and fuse, doesnât appear to occur anywhere else in the body, or even in precancerous conditions, making it a highly specific marker for the disease.When the genes fuse, says study researcher Scott A. Tomlins, MD, PhD, a pathologist at the University of Michigan Health System, in Ann Arbor, itâs a lot like flipping a switch. Our website services, content, and products are for informational purposes only. The results are usually reported as nanograms of PSA per milliliter (ng/mL) of blood. A urinalysis is used to detect and manage a wide range of disorders, such as urinary tract infections, kidney disease and diabetes.A urinalysis involves checking the appearance, concentration and content of urine. Elle est présente dans le sperme où elle joue un rôle dans la reproduction. The PSA test measures the level of PSA in a man’s blood. Abnormal urinalysis results may point to a disease or illness.For example, a urinary tract infection can make urine look cloudy instead of clear. A new urine test could help diagnose aggressive prostate cancer and determine if men with the disease need treatment sooner rather than later.
Researchers say the test can also help determine what type of treatment men should get after diagnosis.The test has the potential to prevent unnecessary, invasive follow-up procedures as well, experts say.The solution, called the Prostate Urine Risk (PUR) test, was created by researchers at the University of East Anglia and the Norfolk and Norwich University Hospital, both in England.The research team used machine learning to assess gene expression in urine samples collected from 537 men.When they looked at the cell-free expression of 167 genes in urine samples, they found a mathematical combination of 35 different genes that could be used to produce the PUR risk signatures.The new test uses four PUR signatures to assess noncancerous tissue and risk groups, which lets doctors know if a person is at low-, intermediate-, or high-risk. Specific means that the test is unlikely to be positive if cancer isnât really present.Based on the levels of PCA3 and TMPRSS2:ERG detected, the men were given numerical scores that were classified as being high, medium, or low.Those scores were then compared to the biopsy results.âThe men in the highest group have a risk of cancer on biopsy of about 70% and those in the lowest group have a risk of cancer of about 20%,â says Tomlins.Researchers then narrowed their analysis to see how the urine test scores matched the menâs Gleason score, which helps doctors gauge how aggressive a cancer may be.âWhat weâve found is that your risk of having an aggressive cancer if youâre in the high group is about 40%, and if youâre in the low group, the risk of having an aggressive cancer is only about 7%,â Tomlins says.The company that developed the test, Gen-Probe, helped to pay for the study, and several authors said they had a personal financial interest in the technology.âThis is great science,â says J. Stephen Jones, MD, chairman of the department of regional urology at the Cleveland Clinic in Ohio.Now that the researchers have validated the test, further studies in larger, more diverse populations will be important to understand how it is best used.âThe real key is using this or any test to help drive decisions,â says Jones, who was not involved in the research, âIf it helps me to know who to biopsy or not biopsy, thatâs massively valuable information.âScott A. Tomlins, MD, PhD, University of Michigan Health System, Ann Arbor.J.
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